2021 Buffalo Bills Roster
| Jersey | POS | Height | Weight | Exp | Age | College | High School | Rating |
|---|---|---|---|---|---|---|---|---|
| 97 | DE | 6-3 | 260 | 11 | 34 | Troy | ||
| 17 | QB | 6-5 | 237 | 4 | 25 | Wyoming | Firebaugh | |
| 96 | DE | 6-3 | 274 | 0 | 23 | Wake Forest | Northside | |
| 2 | K | 5-10 | 183 | 2 | 24 | Georgia Southern | ||
| 71 | OT | 6-4 | 302 | 3 | 24 | Penn State | Archbishop Wood | |
| 11 | WR | 5-8 | 174 | 10 | 32 | SMU | Little Elm | |
| 65 | OG | 6-6 | 313 | 4 | 27 | Iowa | Cedar Falls | |
| 22 | RB | 5-10 | 195 | 5 | 26 | Georgia Southern | Nature Coast Tech | |
| 94 | DT | 6-4 | 330 | 6 | 27 | Louisiana Tech | North Pike | |
| 13 | WR | 6-2 | 210 | 2 | 22 | UCF | Seminole | |
| 73 | OT | 6-5 | 320 | 5 | 27 | Temple | Rahway | |
| 14 | WR | 6-0 | 191 | 7 | 27 | Maryland | Good Counsel | |
| 53 | LB | 6-0 | 237 | 2 | 23 | Texas A&M | Centennial | |
| 77 | OG | 6-4 | 309 | 4 | 29 | Arizona State | Cypress | |
| 72 | OT | 6-8 | 320 | 0 | 23 | Miami (OH) | Edina | |
| 49 | MLB | 6-5 | 250 | 4 | 23 | Virginia Tech | Dan River | |
| 57 | DE | 6-6 | 260 | 2 | 23 | Iowa | Edwardsville | |
| 69 | LS | 6-2 | 235 | 5 | 27 | LSU | Buford | |
| 74 | OG | 6-3 | 329 | 3 | 24 | Oklahoma | Pineville | |
| 41 | FB | 6-0 | 244 | 2 | 24 | Toledo | ||
| 3 | P | 6-0 | 205 | 5 | 27 | Arizona State | Dowling Catholic | |
| 31 | SAF | 6-0 | 200 | 0 | 23 | Pittsburgh | Central Catholic | |
| 68 | OT | 6-5 | 310 | 7 | 27 | Florida State | St. Thomas Aquinas | |
| 55 | DE | 6-2 | 254 | 12 | 33 | TCU | Fort Bend Austin | |
| 23 | SS | 6-0 | 197 | 9 | 30 | Iowa | Fostoria | |
| 30 | CB | 5-11 | 180 | 2 | 24 | Pittsburgh | Quaker Valley | |
| 46 | FS | 5-10 | 191 | 3 | 26 | Miami (FL) | Killian | |
| 24 | CB | 5-11 | 192 | 4 | 25 | Weber State | Sheldon | |
| 25 | RB | 6-0 | 195 | 11 | 33 | Eastern Washington | Deer Valley | |
| 54 | OLB | 6-1 | 240 | 9 | 30 | Iowa State | Kimberly | |
| 88 | TE | 6-4 | 254 | 3 | 25 | Ole Miss | Brentwood Academy | |
| 15 | WR | 6-4 | 209 | 4 | 29 | Wis.-Whitewater | South Elgin | |
| 47 | CB | 5-9 | 183 | 2 | 24 | Buffalo | Voyageur Consortium | |
| 44 | ILB | 6-1 | 235 | 6 | 28 | Temple | ||
| 19 | WR | 5-8 | 173 | 5 | 26 | Georgia | American Heritage | |
| 58 | OLB | 6-0 | 223 | 5 | 27 | Boston College | Dr. Phillips | |
| 60 | C | 6-6 | 305 | 7 | 29 | Missouri | St. Michael's Catholic | |
| 20 | RB | 5-9 | 205 | 2 | 23 | Utah | Hallandale | |
| 33 | DB | 6-0 | 206 | 4 | 27 | Jacksonville State | Abbeville | |
| 93 | DE | 6-6 | 265 | 4 | 29 | Lambeth College | ||
| 91 | DT | 6-1 | 287 | 3 | 23 | Houston | Westfield | |
| 99 | DT | 6-3 | 307 | 4 | 25 | Stanford | Millard West | |
| 21 | FS | 6-0 | 191 | 9 | 30 | Oregon State | Astoria Senior | |
| 50 | DE | 6-6 | 266 | 0 | 21 | Miami (FL) | Champagnat Catholic - Hialeah | |
| 1 | WR | 5-11 | 180 | 12 | 34 | SMU | Bellville | |
| 26 | RB | 5-7 | 203 | 3 | 24 | Florida Atlantic | American Heritage B/D | |
| 59 | LB | 6-0 | 240 | 4 | 24 | North Carolina | Trinity Christian Academy | |
| 5 | WR | 5-10 | 180 | 0 | 23 | Houston | Northwood | |
| 89 | TE | 6-5 | 251 | 3 | 26 | Boston College | Don Bosco Prep | |
| 10 | QB | 6-2 | 220 | 5 | 27 | North Carolina | Mentor | |
| 39 | CB | 6-0 | 179 | 4 | 26 | Alabama | Tucson Magnet | |
| 27 | CB | 5-11 | 192 | 5 | 26 | LSU | Green Oaks | |
| 75 | OT | 6-6 | 330 | 7 | 29 | Oklahoma | Lake Dallas |