2021 Buffalo Bills Schedule
| Pre Season |
|---|
| Opponent |
| @ DET |
| @ CHI |
| GB |
| Reg. Season |
| Opponent |
| PIT |
| @ MIA |
| WAS |
| HOU |
| @ KC |
| @ TEN |
| BYE WEEK |
| MIA |
| @ JAC |
| @ NYJ |
| IND |
| @ NO |
| NE |
| @ TB |
| CAR |
| @ NE |
| ATL |
| NYJ |
| Post Season |
| Opponent |
| NE |
| @ KC |
| - | ||||||
|---|---|---|---|---|---|---|
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 08/13 | 16 - 15 W | 1-0-0 | - | - | NFL Network | |
| 08/21 | 41 - 15 W | 2-0-0 | - | - | NFL Network | |
| 08/28 | 0 - 19 W | 3-0-0 | - | - | NFL Network | |
| - | ||||||
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 09/12 Wk 1 | 23 - 16 L | 3-1-0 | - | - | CBS | |
| 09/19 Wk 2 | 35 - 0 W | 4-1-0 | - | - | FOX | |
| 09/26 Wk 3 | 21 - 43 W | 5-1-0 | - | - | FOX | |
| 10/03 Wk 4 | 0 - 40 W | 6-1-0 | - | - | CBS | |
| 10/10 Wk 5 | 38 - 20 W | 7-1-0 | - | - | NBC | |
| 10/18 Wk 6 | 31 - 34 L | 7-2-0 | - | - | ESPN | |
| - | - | - | - | - | - | - |
| 10/31 Wk 8 | 11 - 26 W | 8-2-0 | - | - | CBS | |
| 11/07 Wk 9 | 6 - 9 L | 8-3-0 | - | - | CBS | |
| 11/14 Wk 10 | 45 - 17 W | 9-3-0 | - | - | CBS | |
| 11/21 Wk 11 | 41 - 15 L | 9-4-0 | - | - | CBS | |
| 11/25 Wk 12 | 31 - 6 W | 10-4-0 | - | - | NBC | |
| 12/06 Wk 13 | 14 - 10 L | 10-5-0 | - | - | ESPN | |
| 12/12 Wk 14 | 27 - 33 L | 10-6-0 | - | - | CBS | |
| 12/19 Wk 15 | 14 - 31 W | 11-6-0 | - | - | FOX | |
| 12/26 Wk 16 | 33 - 21 W | 12-6-0 | - | - | CBS | |
| 01/02 Wk 17 | 15 - 29 W | 13-6-0 | - | - | FOX | |
| 01/09 Wk 18 | 10 - 27 W | 14-6-0 | - | - | CBS | |
| - | ||||||
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 01/15 Wk 19 (Pre) | 17 - 47 W | 15-6-0 | - | - | CBS | |
| 01/23 Wk 20 (Pre) | 36 - 42 L | 15-7-0 | - | - | CBS | |