2022 Buffalo Bills Schedule
| Pre Season |
|---|
| Opponent |
| IND |
| DEN |
| @ CAR |
| Reg. Season |
| Opponent |
| @ LAR |
| TEN |
| @ MIA |
| @ BAL |
| PIT |
| @ KC |
| BYE WEEK |
| GB |
| @ NYJ |
| MIN |
| CLE |
| @ DET |
| @ NE |
| NYJ |
| MIA |
| @ CHI |
| @ CIN |
| NE |
| Post Season |
| Opponent |
| MIA |
| CIN |
| - | ||||||
|---|---|---|---|---|---|---|
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 08/13 | 24 - 27 W | 1-0-0 | - | - | NFL Network | |
| 08/20 | 15 - 42 W | 2-0-0 | - | - | NFL Network | |
| 08/26 | 0 - 21 L | 2-1-0 | - | - | ||
| - | ||||||
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 09/08 Wk 1 | 31 - 10 W | 3-1-0 | - | - | NBC | |
| 09/19 Wk 2 | 7 - 41 W | 4-1-0 | - | - | ESPN Deportes | |
| 09/25 Wk 3 | 19 - 21 L | 4-2-0 | - | - | CBS | |
| 10/02 Wk 4 | 23 - 20 W | 5-2-0 | - | - | CBS | |
| 10/09 Wk 5 | 3 - 38 W | 6-2-0 | - | - | CBS | |
| 10/16 Wk 6 | 24 - 20 W | 7-2-0 | - | - | CBS | |
| - | - | - | - | - | - | - |
| 10/30 Wk 8 | 17 - 27 W | 8-2-0 | - | - | NBC | |
| 11/06 Wk 9 | 17 - 20 L | 8-3-0 | - | - | CBS | |
| 11/13 Wk 10 | 33 - 30 L | 8-4-0 | - | - | FOX | |
| 11/20 Wk 11 | 23 - 31 W | 9-4-0 | - | - | CBS | |
| 11/24 Wk 12 | 28 - 25 W | 10-4-0 | - | - | CBS | |
| 12/01 Wk 13 | 24 - 10 W | 11-4-0 | - | - | Amazon Prime Video | |
| 12/11 Wk 14 | 12 - 20 W | 12-4-0 | - | - | CBS | |
| 12/17 Wk 15 | 29 - 32 W | 13-4-0 | - | - | NFL Network | |
| 12/24 Wk 16 | 35 - 13 W | 14-4-0 | - | - | CBS | |
| 01/02 Wk 17 | Cancelled | - | - | ABC | ||
| 01/08 Wk 18 | 23 - 35 W | 15-4-0 | - | - | CBS | |
| - | ||||||
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 01/15 Wk 19 (Pre) | 31 - 34 W | 16-4-0 | - | - | CBS | |
| 01/22 Wk 20 (Pre) | 27 - 10 L | 16-5-0 | - | - | CBS | |