2021 Indianapolis Colts Schedule
| Pre Season |
|---|
| Opponent |
| CAR |
| @ MIN |
| @ DET |
| Reg. Season |
| Opponent |
| SEA |
| LAR |
| @ TEN |
| @ MIA |
| @ BAL |
| HOU |
| @ SF |
| TEN |
| NYJ |
| JAC |
| @ BUF |
| TB |
| @ HOU |
| BYE WEEK |
| NE |
| @ ARI |
| LV |
| @ JAC |
| - | ||||||
|---|---|---|---|---|---|---|
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 08/15 | 18 - 21 W | 1-0-0 | - | - | NFL Network | |
| 08/21 | 12 - 10 W | 2-0-0 | - | - | ||
| 08/27 | 27 - 17 W | 3-0-0 | - | - | ||
| - | ||||||
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 09/12 Wk 1 | 28 - 16 L | 3-1-0 | - | - | FOX | |
| 09/19 Wk 2 | 27 - 24 L | 3-2-0 | - | - | FOX | |
| 09/26 Wk 3 | 16 - 25 L | 3-3-0 | - | - | CBS | |
| 10/03 Wk 4 | 27 - 17 W | 4-3-0 | - | - | CBS | |
| 10/11 Wk 5 | 25 - 31 L | 4-4-0 | - | - | ESPN | |
| 10/17 Wk 6 | 3 - 31 W | 5-4-0 | - | - | CBS | |
| 10/24 Wk 7 | 30 - 18 W | 6-4-0 | - | - | NBC | |
| 10/31 Wk 8 | 34 - 31 L | 6-5-0 | - | - | CBS | |
| 11/04 Wk 9 | 30 - 45 W | 7-5-0 | - | - | Amazon Prime Video | |
| 11/14 Wk 10 | 17 - 23 W | 8-5-0 | - | - | CBS | |
| 11/21 Wk 11 | 41 - 15 W | 9-5-0 | - | - | CBS | |
| 11/28 Wk 12 | 38 - 31 L | 9-6-0 | - | - | FOX | |
| 12/05 Wk 13 | 31 - 0 W | 10-6-0 | - | - | CBS | |
| - | - | - | - | - | - | - |
| 12/18 Wk 15 | 17 - 27 W | 11-6-0 | - | - | NFL Network | |
| 12/25 Wk 16 | 22 - 16 W | 12-6-0 | - | - | NFL Network | |
| 01/02 Wk 17 | 23 - 20 L | 12-7-0 | - | - | FOX | |
| 01/09 Wk 18 | 11 - 26 L | 12-8-0 | - | - | CBS | |