2021 San Francisco 49ers Roster
| Jersey | POS | Height | Weight | Exp | Age | College | High School | Rating |
|---|---|---|---|---|---|---|---|---|
| 11 | WR | 6-0 | 200 | 2 | 23 | Arizona State | McQueen | |
| 51 | LB | 6-2 | 228 | 3 | 24 | Florida Atlantic | Hillsborough | |
| 91 | DE | 6-7 | 290 | 7 | 27 | Oregon | Pleasant Grove | |
| 65 | OG | 6-5 | 325 | 0 | 24 | Notre Dame | El Cerrito | |
| 97 | DE | 6-4 | 266 | 3 | 23 | Ohio State | St. Thomas Aquinas | |
| 64 | C | 6-4 | 299 | 3 | 29 | UCLA | Plano East | |
| 60 | OT | 6-5 | 300 | 3 | 27 | San Diego State | Valley Center | |
| 36 | RB | 5-11 | 185 | 4 | 27 | Virginia State | Kecoughtan | |
| 66 | OG | 6-6 | 315 | 9 | 32 | South Dakota | Rosemount Senior | |
| 82 | TE | 6-5 | 235 | 4 | 26 | San Diego | ||
| 56 | DE | 6-3 | 245 | 5 | 26 | Eastern Washington | Douglas | |
| 45 | LB | 6-2 | 223 | 2 | 25 | Arizona | Mountain View | |
| 55 | DE | 6-2 | 252 | 8 | 30 | Auburn | St. Clair County | |
| 10 | QB | 6-2 | 225 | 8 | 29 | Eastern Illinois | Rolling Meadows | |
| 90 | DT | 6-1 | 285 | 2 | 24 | Penn State | Altoona | |
| 9 | K | 6-0 | 190 | 17 | 38 | Penn State | Central Mountain | |
| 36 | LB | 6-0 | 215 | 4 | 27 | Florida | Dr. Phillips | |
| 23 | RB | 5-8 | 205 | 2 | 25 | Baylor | Longview | |
| 29 | SAF | 6-0 | 200 | 0 | 22 | USC | Crescent Valley | |
| 15 | WR | 6-3 | 212 | 1 | 24 | Tennessee | Blackman | |
| 27 | DB | 6-2 | 200 | 8 | 29 | NC State | The Pennington School | |
| 93 | DT | 6-0 | 305 | 5 | 26 | Ole Miss | Wren | |
| 44 | FB | 6-1 | 235 | 9 | 30 | Harvard | Cloverleaf | |
| 92 | DE | 6-2 | 334 | 8 | 31 | Delaware | Quince Orchard | |
| 98 | DE | 6-5 | 240 | 4 | 25 | LSU | Hapeville Charter | |
| 99 | DT | 6-5 | 319 | 2 | 23 | South Carolina | Goose Creek | |
| 20 | CB | 6-2 | 190 | 10 | 31 | Alabama | Gadsden City | |
| 85 | TE | 6-4 | 250 | 5 | 27 | Iowa | Norman | |
| 5 | QB | 6-4 | 226 | 0 | 21 | North Dakota State | Marshall | |
| 38 | CB | 5-10 | 200 | 0 | 21 | Oregon | Salesian | |
| 50 | C | 6-4 | 311 | 13 | 35 | California | San Marcos Senior | |
| 69 | OT | 6-8 | 310 | 4 | 26 | Notre Dame | William Penn Charter | |
| 25 | RB | 5-10 | 200 | 0 | 23 | Louisiana | Erath | |
| 76 | OT | 6-4 | 311 | 0 | 23 | Western Michigan | Voyageur Consortium | |
| 4 | DB | 5-11 | 190 | 4 | 25 | Tennessee | Dudley | |
| 26 | CB | 6-0 | 200 | 10 | 33 | Coastal Carolina | Greenwood | |
| 46 | LS | 6-4 | 245 | 4 | 27 | Michigan State | Saline | |
| 19 | WR | 6-0 | 215 | 3 | 25 | South Carolina | Chapman Hi | |
| 6 | WR | 6-2 | 210 | 10 | 32 | Rutgers | South Brunswick | |
| 28 | RB | 6-0 | 215 | 0 | 22 | Ohio State | Sprayberry | |
| 81 | WR | 6-1 | 219 | 4 | 25 | Vanderbilt | Danville | |
| 95 | DE | 6-2 | 287 | 3 | 25 | NC State | J.H. Rose | |
| 3 | SS | 6-1 | 215 | 7 | 29 | Samford | WP Davidson | |
| 20 | CB | 6-0 | 190 | 0 | 22 | Michigan | Martin Luther King | |
| 75 | OG | 6-3 | 315 | 7 | 29 | Duke | Lane Technical | |
| 1 | CB | 5-11 | 195 | 8 | 30 | Northern Illinois | WP Davidson | |
| 54 | MLB | 6-3 | 230 | 4 | 24 | BYU | Mission Hills | |
| 24 | DB | 5-9 | 185 | 7 | 30 | Pittsburgh | St Joseph Regional | |
| 71 | OT | 6-5 | 320 | 11 | 33 | Oklahoma | Longview | |
| 78 | DE | 6-4 | 270 | 5 | 26 | Kansas State | Rockhurst | |
| 32 | DB | 6-0 | 208 | 10 | 31 | Illinois | Unknown | |
| 6 | P | 6-2 | 220 | 3 | 29 | Utah | ||
| 89 | TE | 6-5 | 241 | 2 | 23 | Georgia | Rabun County |