2022 San Francisco 49ers Schedule
| Pre Season |
|---|
| Opponent |
| GB |
| @ MIN |
| @ HOU |
| Reg. Season |
| Opponent |
| @ CHI |
| SEA |
| @ DEN |
| LAR |
| @ CAR |
| @ ATL |
| KC |
| @ LAR |
| BYE WEEK |
| LAC |
| @ ARI |
| NO |
| MIA |
| TB |
| @ SEA |
| WAS |
| @ LV |
| ARI |
| Post Season |
| Opponent |
| SEA |
| DAL |
| @ PHI |
| - | ||||||
|---|---|---|---|---|---|---|
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 08/12 | 21 - 28 W | 1-0-0 | - | - | NFL Network | |
| 08/20 | 17 - 7 W | 2-0-0 | - | - | ||
| 08/25 | 0 - 17 L | 2-1-0 | - | - | Amazon Prime Video | |
| - | ||||||
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 09/11 Wk 1 | 10 - 19 L | 2-2-0 | - | - | FOX | |
| 09/18 Wk 2 | 7 - 27 W | 3-2-0 | - | - | FOX | |
| 09/25 Wk 3 | 10 - 11 L | 3-3-0 | - | - | NBC | |
| 10/03 Wk 4 | 9 - 24 W | 4-3-0 | - | - | ESPN2 | |
| 10/09 Wk 5 | 37 - 15 W | 5-3-0 | - | - | CBS | |
| 10/16 Wk 6 | 14 - 28 L | 5-4-0 | - | - | FOX | |
| 10/23 Wk 7 | 44 - 23 L | 5-5-0 | - | - | FOX | |
| 10/30 Wk 8 | 31 - 14 W | 6-5-0 | - | - | FOX | |
| - | - | - | - | - | - | - |
| 11/13 Wk 10 | 16 - 22 W | 7-5-0 | - | - | NBC | |
| 11/21 Wk 11 | 38 - 10 W | 8-5-0 | - | - | ESPN Deportes | |
| 11/27 Wk 12 | 0 - 13 W | 9-5-0 | - | - | FOX | |
| 12/04 Wk 13 | 17 - 33 W | 10-5-0 | - | - | FOX | |
| 12/11 Wk 14 | 7 - 35 W | 11-5-0 | - | - | FOX | |
| 12/15 Wk 15 | 21 - 13 W | 12-5-0 | - | - | Amazon Prime Video | |
| 12/24 Wk 16 | 20 - 37 W | 13-5-0 | - | - | CBS | |
| 01/01 Wk 17 | 37 - 34 W | 14-5-0 | - | - | FOX | |
| 01/08 Wk 18 | 13 - 38 W | 15-5-0 | - | - | FOX | |
| - | ||||||
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 01/14 Wk 19 (Pre) | 23 - 41 W | 16-5-0 | - | - | FOX | |
| 01/22 Wk 20 (Pre) | 12 - 19 W | 17-5-0 | - | - | FOX | |
| 01/29 Wk 21 (Pre) | 7 - 31 L | 17-6-0 | - | - | FOX | |