2019 San Francisco 49ers Schedule
| Pre Season |
|---|
| Opponent |
| DAL |
| @ DEN |
| @ KC |
| LAC |
| Reg. Season |
| Opponent |
| @ TB |
| @ CIN |
| PIT |
| BYE WEEK |
| CLE |
| @ LAR |
| @ WAS |
| CAR |
| @ ARI |
| SEA |
| ARI |
| GB |
| @ BAL |
| @ NO |
| ATL |
| LAR |
| @ SEA |
| Post Season |
| Opponent |
| MIN |
| GB |
| @ KC |
| - | ||||||
|---|---|---|---|---|---|---|
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 08/10 | 9 - 17 W | 1-0-0 | - | - | NFL Network | |
| 08/19 | 24 - 15 W | 2-0-0 | -1.0 | 40.5 | ESPN | |
| 08/24 | 27 - 17 W | 3-0-0 | - | - | ||
| 08/29 | 27 - 24 L | 3-1-0 | - | - | NFL Network | |
| - | ||||||
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 09/08 Wk 1 | 31 - 17 W | 4-1-0 | +1.0 | 49.5 | FOX | |
| 09/15 Wk 2 | 41 - 17 W | 5-1-0 | - | - | FOX | |
| 09/22 Wk 3 | 20 - 24 W | 6-1-0 | - | - | CBS | |
| - | - | - | - | - | - | - |
| 10/07 Wk 5 | 3 - 31 W | 7-1-0 | - | - | ESPN | |
| 10/13 Wk 6 | 20 - 7 W | 8-1-0 | - | - | FOX | |
| 10/20 Wk 7 | 9 - 0 W | 9-1-0 | - | - | FOX | |
| 10/27 Wk 8 | 13 - 51 W | 10-1-0 | - | - | FOX | |
| 10/31 Wk 9 | 28 - 25 W | 11-1-0 | - | - | Amazon Prime Video | |
| 11/11 Wk 10 | 27 - 24 L | 11-2-0 | -6.0 | 47.0 | ESPN | |
| 11/17 Wk 11 | 26 - 36 W | 12-2-0 | - | - | FOX | |
| 11/24 Wk 12 | 8 - 37 W | 13-2-0 | - | - | NBC | |
| 12/01 Wk 13 | 17 - 20 L | 13-3-0 | - | - | FOX | |
| 12/08 Wk 14 | 48 - 46 W | 14-3-0 | - | - | FOX | |
| 12/15 Wk 15 | 29 - 22 L | 14-4-0 | - | - | FOX | |
| 12/21 Wk 16 | 31 - 34 W | 15-4-0 | - | - | NFL Network | |
| 12/29 Wk 17 | 26 - 21 W | 16-4-0 | - | - | NBC | |
| - | ||||||
| Date | Status | Record | Spread | O/U | Tickets | Network |
| 01/11 Wk 19 (Pre) | 10 - 27 W | 17-4-0 | - | - | NBC | |
| 01/19 Wk 20 (Pre) | 20 - 37 W | 18-4-0 | - | - | FOX | |
| 02/02 Wk 22 (Pre) | 20 - 31 L | 18-5-0 | - | - | FOX | |